An isoxazole strategy for the synthesis of 4-oxo-1,4-dihydropyridine-3-carboxylates

• Timur O. Zanakhov,
• Ekaterina E. Galenko,
• Mikhail S. Novikov and
• Alexander F. Khlebnikov

Beilstein J. Org. Chem. 2022, 18, 738–745, doi:10.3762/bjoc.18.74

• -triaryl-substituted and 1,2,5,6-tetrasubstituted nicotinates. Keywords: isoxazole; methyl nicotinate; molybdenum hexacarbonyl; 4-pyridone; ring expansion; Introduction Pyridine moieties are present in many natural products, drugs, pesticides and industrial materials. Pyridine fragments are used in drugs

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

• Christoph W. Grathwol,
• Nathalie Wössner,
• Sören Swyter,
• Adam C. Smith,
• Enrico Tapavicza,
• Robert K. Hofstetter,
• Anja Bodtke,
• Manfred Jung and
• Andreas Link

Beilstein J. Org. Chem. 2019, 15, 2170–2183, doi:10.3762/bjoc.15.214

• determination of elemental configurations of final pure products. UV–vis spectra were obtained using a Thermo Scientific Genesys 10S UV–vis spectrophotometer. Synthesis General procedure for synthesis of nicotinamides from methyl nicotinates: The respective methyl nicotinate was treated with a saturated

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives

• Mikhail V. Makarov and
• Marie E. Migaud

Beilstein J. Org. Chem. 2019, 15, 401–430, doi:10.3762/bjoc.15.36

• this reaction revealed that it proceeded via the methyl nicotinate 18 which could be isolated when the transformation was carried out at −20 °C. These results indicated that methoxide is more reactive than ammonia in reacting with ester 17. A very detailed synthetic procedure for the preparation of β

The volatiles of pathogenic and nonpathogenic mycobacteria and related bacteria

• Thorben Nawrath,
• Georgies F. Mgode,
• Bart Weetjens,
• Stefan H. E. Kaufmann and
• Stefan Schulz

Beilstein J. Org. Chem. 2012, 8, 290–299, doi:10.3762/bjoc.8.31

• studies, volatiles were collected by using solid-phase micro-extraction (SPME). Methyl phenylacetate (1), methyl p-anisate (2), methyl nicotinate (3), and o-phenylanisole (4) were emitted by pathogenic M. bovis and M. tuberculosis (Figure 1), while nontuberculous mycobacteria did not produce these four

• produced by other bacteria, but also including relatively specific compounds such as methyl nicotinate (3). Variations occurred within individual analyses and also between different media. Therefore, it seems unlikely that GC–MS analyses of individual cultures can be used as a diagnostic tool. Nevertheless